While the role of protein synthesis in synaptic plasticity and memory is well-established, protein degradation processes have been less studied. A seminal 2003 Nature Neuroscience paper showed that ubiquitin-dependent degradation of synaptic proteins is engaged during activity-regulated synaptic remodeling.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 per month
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Sutton, M. A. & Schuman, E. M. Cell 127, 49–58 (2006).
Hershko, A. & Ciechanover, A. Annu. Rev. Biochem. 67, 425–479 (1998).
Matsuura, T. et al. Nat. Genet. 15, 74–77 (1997).
Ehlers, M. D. Nat. Neurosci. 6, 231–242 (2003).
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C. & Nelson, S. B. Nature 391, 892–896 (1998).
Frank, R. A. & Grant, S. G. Curr. Opin. Neurobiol. 45, 139–147 (2017).
Chen, H., Tang, A. H. & Blanpied, T. A. Curr. Opin. Neurobiol. 51, 147–153 (2018).
Bingol, B. & Schuman, E. M. Nature 441, 1144–1148 (2006).
Bingol, B. et al. Cell 140, 567–578 (2010).
Lee, S. H. et al. Science 319, 1253–1256 (2008).
Fonseca, R., Vabulas, R. M., Hartl, F. U., Bonhoeffer, T. & Nägerl, U. V. Neuron 52, 239–245 (2006).
George, A. J., Hoffiz, Y. C., Charles, A. J., Zhu, Y. & Mabb, A. M. Front. Genet. 9, 29 (2018).
Shepherd, J. D. & Bear, M. F. Nat. Neurosci. 14, 279–284 (2011).
Wall, M. J. et al. Neuron 98, 1124–1132.e7 (2018).
Pastuzyn, E. D. & Shepherd, J. D. Front. Mol. Neurosci. 10, 234 (2017).
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Shepherd, J.D. Deconstructing the synapse. Nat Neurosci 21, 1294–1295 (2018). https://doi.org/10.1038/s41593-018-0244-8