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HISTORICAL NEWS & VIEWS: SYNAPTIC PLASTICITY

Deconstructing the synapse

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While the role of protein synthesis in synaptic plasticity and memory is well-established, protein degradation processes have been less studied. A seminal 2003 Nature Neuroscience paper showed that ubiquitin-dependent degradation of synaptic proteins is engaged during activity-regulated synaptic remodeling.

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The author declares no competing interests.

Correspondence to Jason D. Shepherd.

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Fig. 1: Activity-dependent remodeling of synaptic proteins.