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The diverse culinary habits of microglia

Heterogeneity of function in microglia from different brain regions is suspected but largely unknown. This paper identifies the epigenetic mechanism underlying differential phagocytic activity of microglia in discrete brain regions and examines the consequences of inducing an appetite not commensurate with the level of cell death in the region in which they reside.

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Fig. 1: Epigenetic programming of microglia in different brain regions maintains distinct levels of cell clearance.


  1. Aguzzi, A., Barres, B. A. & Bennett, M. L. Science 339, 156–161 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. Bilbo, S. D. & Schwarz, J. M. Front. Neuroendocrinol. 33, 267–286 (2012).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Weinhard, L. et al. Nat. Commun. 9, 1228 (2018).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Stevens, B. & Schafer, D. P. Dev. Neurobiol. 78, 559–560 (2018).

    Article  PubMed  Google Scholar 

  5. Ayata, P. et al.. Nat. Neurosci. (2018).

  6. Ginhoux, F. et al. Science 330, 841–845 (2010).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Ransohoff, R. M. Nat. Neurosci. 19, 987–991 (2016).

    Article  PubMed  CAS  Google Scholar 

  8. Deczkowska, A. et al. Cell 173, 1073–1081 (2018).

    Article  PubMed  CAS  Google Scholar 

  9. Zhang, K. et al. Brain Behav. Immun. 71, 18–22 (2018).

    Article  PubMed  CAS  Google Scholar 

Download references

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Correspondence to Staci D. Bilbo.

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Bilbo, S.D. The diverse culinary habits of microglia. Nat Neurosci 21, 1023–1025 (2018).

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