Protein kinases are key regulators of excitatory synapse plasticity. In this issue, using novel optical reporters of protein kinase C (PKC) activity, Colgan et al. identify PKCα as critical for integrating NMDA receptor and neurotrophin signaling to control dendritic spine structural plasticity, synaptic potentiation, and learning and memory.
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References
Colgan, L.A. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-018-0184-3 (2018).
Martin, K. J. & Arthur, J. S. Neuropharmacology 63, 1227–1237 (2012).
Woolfrey, K. M. & Dell’Acqua, M. L. J. Biol. Chem. 290, 28604–28612 (2015).
Hanley, J. G. & Henley, J. M. EMBO J. 24, 3266–3278 (2005).
O’Neill, A. K. et al. J. Biol. Chem. 286, 43559–43568 (2011).
Staudinger, J., Lu, J. & Olson, E. N. J. Biol. Chem. 272, 32019–32024 (1997).
Zhu, J., Shang, Y. & Zhang, M. Nat. Rev. Neurosci. 17, 209–223 (2016).
Gruart, A., Sciarretta, C., Valenzuela-Harrington, M., Delgado-García, J. M. & Minichiello, L. Learn. Mem. 14, 54–62 (2007).
Harward, S. C. et al. Nature 538, 99–103 (2016).
Lucke-Wold, B. P. et al. J. Alzheimers Dis. 43, 711–724 (2015).
Callender, J.A. et al. Proc. Natl. Acad. Sci. USA 115, E5497–E5505 (2018).
Alfonso, S. I. et al. Sci. Signal. 9, ra47 (2016).
Maglione, M. & Sigrist, S. J. Nat. Neurosci. 16, 790–797 (2013).
Gross, G. G. et al. Neuron 78, 971–985 (2013).
Mikuni, T., Nishiyama, J., Sun, Y., Kamasawa, N. & Yasuda, R. Cell 165, 1803–1817 (2016).
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Dell’Acqua, M.L., Woolfrey, K.M. FRETting over postsynaptic PKC signaling. Nat Neurosci 21, 1021–1022 (2018). https://doi.org/10.1038/s41593-018-0190-5
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DOI: https://doi.org/10.1038/s41593-018-0190-5