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Stressing the other paraventricular nucleus

Nature Neurosciencevolume 21pages901902 (2018) | Download Citation

Often overlooked, the paraventricular nucleus of the thalamus is a stress-sensitive region in the midline thalamus essential for stress-induced adaptations. Using cutting edge in vivo monitoring approaches, Beas, Wright et al. identify a circuit by which stress disinhibits the midline thalamus through dopaminergic modulation arising from the locus coeruleus.

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Affiliations

  1. Department of Psychological & Brain Sciences, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD, USA

    • Kurt M. Fraser
    •  & Patricia H. Janak
  2. The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA

    • Patricia H. Janak
  3. Kavli Neuroscience Discovery Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA

    • Patricia H. Janak

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Competing interests

The authors declare no competing interests.

Corresponding authors

Correspondence to Kurt M. Fraser or Patricia H. Janak.

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DOI

https://doi.org/10.1038/s41593-018-0178-1