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NEURODEGENERATIVE DISEASE

Modeling Alzheimer’s disease brains in vitro

Nature Neuroscience volume 21, pages 899–900 (2018)Cite this article

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Alzheimer’s disease (AD) research is hampered by a lack of models that recapitulate all key disease features. Park et al. introduce a microfluidic device containing a 3D culture of human neurons, astrocytes, and microglia that develop AD-like pathology, revealing a potentially important inflammatory mechanism of neurodegeneration.

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Fig. 1: Park et al. developed a new 3D triculture system.

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Authors and Affiliations

  1. UK Dementia Research Institute and Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK

    Christopher M. Henstridge & Tara L. Spires-Jones

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  1. Christopher M. Henstridge
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  2. Tara L. Spires-Jones
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Correspondence to Tara L. Spires-Jones.

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The authors declare no competing interests.

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Henstridge, C.M., Spires-Jones, T.L. Modeling Alzheimer’s disease brains in vitro. Nat Neurosci 21, 899–900 (2018). https://doi.org/10.1038/s41593-018-0177-2

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