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Baby brains reflect maternal inflammation

Epidemiology and animal research have shown that the offspring of mothers who experience inflammation during pregnancy are at increased risk for psychopathology. A human study links a mother’s inflammation during pregnancy to her newborn’s functional brain organization and the child’s working memory two years later.

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References

  1. 1.

    Mennella, J. A., Jagnow, C. P. & Beauchamp, G. K. Pediatrics 107, E88 (2001).

  2. 2.

    Mehler, J. et al. Cognition 29, 143–178 (1988).

  3. 3.

    Rudolph, M. D. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-018-0128-y (2018).

  4. 4.

    Alexander, G. R. & Kotelchuck, M. Public Health Rep. 116, 306–316 (2001).

  5. 5.

    Guerrini, I., Thomson, A. D. & Gurling, H. D. Neurosci. Biobehav. Rev. 31, 212–220 (2007).

  6. 6.

    Brown, A. S. Dev. Neurobiol. 72, 1272–1276 (2012).

  7. 7.

    Estes, M. L. & McAllister, A. K. Science 353, 772–777 (2016).

  8. 8.

    Smith, S. E. P., Li, J., Garbett, K., Mirnics, K. & Patterson, P. H. J. Neurosci. 27, 10695–10702 (2007).

  9. 9.

    Graham, A. M. et al. Biol. Psychiatry 83, 109–119 (2018).

  10. 10.

    Scheller, J., Chalaris, A., Schmidt-Arras, D. & Rose-John, S. Biochim. Biophys. Acta 1813, 878–888 (2011).

  11. 11.

    Yarkoni, T., Poldrack, R. A., Nichols, T. E., Van Essen, D. C. & Wager, T. D. Nat. Methods 8, 665–670 (2011).

  12. 12.

    Hughes, C. & Ensor, R. Dev. Psychol 43, 1447–1459 (2007).

  13. 13.

    Scheinost, D. et al. Pediatr. Res. 81, 214–226 (2017).

  14. 14.

    Spann, M. N., Monk, C., Scheinost, D. & Peterson, B. S. J. Neurosci. 38, 2877–2876 (2018).

  15. 15.

    Rosenberg, M. D., Casey, B. J. & Holmes, A. J. Nat. Commun. 9, 589 (2018).

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Author information

Affiliations

  1. Department of Psychology, Yale University, New Haven, CT, USA

    • Monica D. Rosenberg

Authors

  1. Search for Monica D. Rosenberg in:

Competing interests

The author declares no competing interests.

Corresponding author

Correspondence to Monica D. Rosenberg.