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Microglia’s heretical self-renewal

Nature Neurosciencevolume 21pages455456 (2018) | Download Citation

The dogma that self-renewal is a defining characteristic of stem cells, which stemmed from studies of the hematopoietic hierarchy and quickly spread by analogy to all tissues, has been shattered by scientists pointing a microscope at the hematopoietic system itself. A microglial cell is clearly fully differentiated, and yet it self-renews.

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Author information

Affiliations

  1. School of Biomedical Engineering and The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada

    • Fabio Rossi
  2. STEMCELL Technologies, Vancouver, BC, Canada

    • Coral Lewis

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Competing interests

The authors declare no competing interests.

Corresponding authors

Correspondence to Fabio Rossi or Coral Lewis.

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DOI

https://doi.org/10.1038/s41593-018-0123-3

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