The dogma that self-renewal is a defining characteristic of stem cells, which stemmed from studies of the hematopoietic hierarchy and quickly spread by analogy to all tissues, has been shattered by scientists pointing a microscope at the hematopoietic system itself. A microglial cell is clearly fully differentiated, and yet it self-renews.
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Rossi, F., Lewis, C. Microglia’s heretical self-renewal. Nat Neurosci 21, 455–456 (2018). https://doi.org/10.1038/s41593-018-0123-3
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DOI: https://doi.org/10.1038/s41593-018-0123-3
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