U-turns in the brain

When making decisions, new information sometimes calls for a change of mind. New results indicate that regions of the prefrontal cortex play distinct roles in evaluating new evidence in light of a previous choice and translating the result of this evaluation process into an explicit report of one’s subjective confidence.

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Fig. 1: Neural mediators of changes of mind.


  1. 1.

    Fleming, S. M., van der Putten, E. J. & Daw, N. D. Nat. Neurosci. https://doi.org/10.1038/s41593-018-0104-6 (2018).

  2. 2.

    Nelson, T. O. & Narens, L. Metamemory: a theoretical framework and new findings. in The Psychology of Learning and Motivation: Advances in Research and Theory (ed. Bower, G.H.) 125–173 (Academic, New York, 1990).

  3. 3.

    Ridderinkhof, K. R., Ullsperger, M., Crone, E. A. & Nieuwenhuis, S. Science 306, 443–447 (2004).

    CAS  Article  PubMed  Google Scholar 

  4. 4.

    Fleming, S. M. & Dolan, R. J. Phil. Trans. R. Soc. Lond. B 367, 1338–1349 (2012).

    Article  Google Scholar 

  5. 5.

    Yeung, N. & Summerfield, C. Phil. Trans. R. Soc. Lond. B 367, 1310–1321 (2012).

    Article  Google Scholar 

  6. 6.

    Rounis, E., Maniscalco, B., Rothwell, J. C., Passingham, R. E. & Lau, H. Cogn. Neurosci. 1, 165–175 (2010).

    Article  PubMed  Google Scholar 

  7. 7.

    Pannu, J. K. & Kaszniak, A. W. Neuropsychol. Rev. 15, 105–130 (2005).

    Article  PubMed  Google Scholar 

  8. 8.

    Fleming, S. M. et al. Psychol. Sci. 26, 89–98 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  9. 9.

    Shadlen, M. N. & Kiani, R. Neuron 80, 791–806 (2013).

    CAS  Article  PubMed  Google Scholar 

  10. 10.

    Fleming, S. M., Huijgen, J. & Dolan, R. J. J. Neurosci. 32, 6117–6125 (2012).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  11. 11.

    Pleskac, T. J. & Busemeyer, J. R. Psychol. Rev. 117, 864–901 (2010).

    Article  PubMed  Google Scholar 

  12. 12.

    van den Berg, R. et al. eLife 5, e12192 (2016).

    PubMed  PubMed Central  Google Scholar 

  13. 13.

    Cavanagh, J. F. & Frank, M. J. Trends Cogn. Sci. 18, 414–421 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  14. 14.

    Cohen, M. X. & Donner, T. H. J. Neurophysiol. 110, 2752–2763 (2013).

    Article  PubMed  Google Scholar 

  15. 15.

    Murphy, P. R., Robertson, I. H., Harty, S. & O’Connell, R. G. eLife https://doi.org/10.7554/eLife.11946 (2015).

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Correspondence to Redmond G. O’Connell.

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O’Connell, R.G., Murphy, P.R. U-turns in the brain. Nat Neurosci 21, 461–462 (2018). https://doi.org/10.1038/s41593-018-0122-4

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