Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

SPINAL CORD INJURY

A brainstem bypass for spinal cord injury

Nature Neuroscience volume 21, pages 457–458 (2018)Cite this article

Subjects

Spinal cord injury disrupts connectivity between the brain and the body. With electrochemical neuromodulation and intensive rehabilitation training, the cortex can functionally connect with spinal circuits below injury by relaying signals through the brainstem.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1

References

  1. Hilton, B. J. & Bradke, F. Development 144, 3417–3429 (2017).

    Article  PubMed  Google Scholar 

  2. Taccola, G., Sayenko, D., Gad, P., Gerasimenko, Y. & Edgerton, V. Prog. Neurobiol. 160, 64–81 (2017).

    Article  PubMed  Google Scholar 

  3. Asboth, L. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-018-0093-5 (2018).

    PubMed  Google Scholar 

  4. Kakulas, B. A. & Kaelan, C. Clin. Neurol. Neurosurg. 129, S1–S7 (2015). Suppl 1.

    Article  PubMed  Google Scholar 

  5. van den Brand, R. et al. Science 336, 1182–1185 (2012).

    Article  PubMed  Google Scholar 

  6. Sekhon, L. H. & Fehlings, M. G. Spine 26 Suppl, S2–S12 (2001).

    Article  Google Scholar 

  7. Sławińska, U. et al. Science 338, 328–328 (2012).author reply 328.

    PubMed  Google Scholar 

  8. Sławińska, U., Majczyński, H., Dai, Y. & Jordan, L. M. J. Physiol. (Lond.) 590, 1721–1736 (2012).

    Article  PubMed Central  Google Scholar 

  9. Miri, A. et al. Neuron 95, 683–696 e11 (2017).

    Article  CAS  PubMed  Google Scholar 

  10. Hilton, B. J. et al. J. Neurosci. 36, 4080–4092 (2016).

    Article  PubMed  Google Scholar 

  11. Ishida, A. et al. J. Neurosci. 36, 455–467 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Esposito, M. S., Capelli, P. & Arber, S. Nature 508, 351–356 (2014).

    Article  CAS  PubMed  Google Scholar 

  13. Rosenzweig, E. S. et al. Nat. Neurosci. 13, 1505–1510 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Guertin, P. A. Curr. Pharm. Des. 23, 1778–1788 (2017).

  15. Mosberger, A. C. et al. Cereb. Cortex 28, 625–643 (2018).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory for Axon Growth and Regeneration, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany

    Brett J Hilton

  2. International Collaboration on Repair Discoveries, Depts of Zoology and Surgery, University of British Columbia, Vancouver, Canada

    Wolfram Tetzlaff

Authors
  1. Brett J Hilton
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wolfram Tetzlaff
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Brett J Hilton or Wolfram Tetzlaff.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hilton, B.J., Tetzlaff, W. A brainstem bypass for spinal cord injury. Nat Neurosci 21, 457–458 (2018). https://doi.org/10.1038/s41593-018-0099-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41593-018-0099-z

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing