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Huntington modeling improves with age

Nature Neuroscience volume 21, pages 301–303 (2018)Cite this article

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Direct conversion of adult Huntington’s disease patient fibroblasts into medium spiny neurons recapitulates hallmark phenotypes such as cell death, in contrast to models that lack epigenetic markers of aging. This successful ‘disease-in-a-dish’ highlights the benefits of capturing age in an adult-onset disorder model.

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Fig. 1: Key results from Victor et al.1.

Katie Vicari/Springer Nature.

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Authors and Affiliations

  1. The Board of Governors Regenerative Medicine Institute and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA

    Virginia B. Mattis & Clive N. Svendsen

Authors
  1. Virginia B. Mattis
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  2. Clive N. Svendsen
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Correspondence to Clive N. Svendsen.

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The authors declare no competing financial interests.

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Mattis, V.B., Svendsen, C.N. Huntington modeling improves with age. Nat Neurosci 21, 301–303 (2018). https://doi.org/10.1038/s41593-018-0086-4

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