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NEUROIMMUNOLOGY

Skip the salt: your brain might thank you

Nature Neuroscience volume 21, pages 154–155 (2018)Cite this article

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Excessive dietary salt can impair cerebral blood flow regulation, resulting in cognitive dysfunction in mice. A ‘gut–brain’ pathway is implicated that links expansion of TH17 lymphocytes in small intestine to elevated bloodstream interleukin-17, which impairs brain perfusion by decreasing nitric oxide production in brain vascular endothelium.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Columbia University, New York, NY, USA

    Mohammed A. Shaik & Elizabeth M. C. Hillman

  2. Mortimer B. Zuckerman Mind Brain Behavior Institute, New York, NY, USA

    Elizabeth M. C. Hillman

Authors
  1. Mohammed A. Shaik
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  2. Elizabeth M. C. Hillman
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Correspondence to Elizabeth M. C. Hillman.

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The authors declare no competing financial interests.

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Shaik, M.A., Hillman, E.M.C. Skip the salt: your brain might thank you. Nat Neurosci 21, 154–155 (2018). https://doi.org/10.1038/s41593-018-0068-6

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