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NEURODEGENERATION

Nuclear pores: the gate to neurodegeneration

Nature Neurosciencevolume 21pages156158 (2018) | Download Citation

Compromised compartmentalization of nucleus and cytoplasm has emerged as a central feature of aging and neurodegenerative diseases. Nucleocytoplasmic transport is disrupted, with widespread mislocalization of nuclear pore proteins, in TDP-43 proteinopathies such as, amyotrophic lateral sclerosis and frontotemporal dementia.

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Author information

Affiliations

  1. MassGeneral Institute for Neurodegenerative Disease (MIND), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    • Nan Li
    •  & Clotilde Lagier-Tourenne
  2. Broad Institute of MIT and Harvard, Cambridge, MA, USA

    • Clotilde Lagier-Tourenne

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Clotilde Lagier-Tourenne.

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DOI

https://doi.org/10.1038/s41593-017-0066-0

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