Compromised compartmentalization of nucleus and cytoplasm has emerged as a central feature of aging and neurodegenerative diseases. Nucleocytoplasmic transport is disrupted, with widespread mislocalization of nuclear pore proteins, in TDP-43 proteinopathies such as, amyotrophic lateral sclerosis and frontotemporal dementia.
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Author information
Affiliations
MassGeneral Institute for Neurodegenerative Disease (MIND), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
- Nan Li
- & Clotilde Lagier-Tourenne
Broad Institute of MIT and Harvard, Cambridge, MA, USA
- Clotilde Lagier-Tourenne
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The authors declare no competing financial interests.
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Correspondence to Clotilde Lagier-Tourenne.
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