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OREXIN

Stay alert, don’t get hurt

Both nucleus accumbens and orexin play clear roles in motivated behavior, but the functions of orexin projections to accumbens are poorly understood. Blomeley et al. show that this pathway, via specific orexin excitation of dopamine D2 receptor–expressing neurons, can inhibit reward seeking and exploratory drive when danger is perceived.

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Change history

  • 11 May 2018

    In the version of this article initially published, paragraph 8 mentioned intra-accumbens administration of SB334867. This should have read systemic (intraperitoneal) administration. The error has been corrected in the HTML and PDF versions of the article.

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Correspondence to Stephen V. Mahler.

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Fig. 1: An orexinergic input to nucleus accumbens that promotes risk avoidance.