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MYELINATION

Calcium control of myelin sheath growth

New studies provide compelling evidence that the number and length of myelin sheaths generated by oligodendrocytes in the CNS are controlled by local calcium levels, linking axonal activity to individual myelin sheath formation.

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Fig. 1: An individual oligodendrocyte can generate multiple myelin sheaths that wrap different axons.

References

  1. Baraban, M., Koudelka, S. & Lyons, D.A. Nat. Neurosci. https://dx.doi.org/10.1038/s41593-017-0040-x (2017).

  2. Krasnow, A.M., Ford, M.C., Valdivia, L.E., Wilson, S.W. & Attwell, D. Nat. Neurosci. https://dx.doi.org/10.1038/s41593-017-0031-y (2017).

  3. Ford, M. C. et al. Nat. Commun. 6, 8073 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Watkins, T. A., Emery, B., Mulinyawe, S. & Barres, B. A. Neuron 60, 555–569 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Hines, J. H., Ravanelli, A. M., Schwindt, R., Scott, E. K. & Appel, B. Nat. Neurosci. 18, 683–689 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Wake, H., Lee, P. R. & Fields, R. D. Science 333, 1647–1651 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Barres, B. A. & Raff, M. C. Nature 361, 258–260 (1993).

    Article  CAS  PubMed  Google Scholar 

  8. Bergles, D. E., Roberts, J. D., Somogyi, P. & Jahr, C. E. Nature 405, 187–191 (2000).

    Article  CAS  PubMed  Google Scholar 

  9. Zuchero, J. B. et al. Dev. Cell 34, 152–167 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Young, K. M. et al. Neuron 77, 873–885 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. McKenzie, I. A. et al. Science 346, 318–322 (2014).

    Article  CAS  PubMed  Google Scholar 

  12. Xiao, L. et al. Nat. Neurosci. 19, 1210–1217 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Chang, A., Tourtellotte, W. W., Rudick, R. & Trapp, B. D. N. Engl. J. Med. 346, 165–173 (2002).

    Article  PubMed  Google Scholar 

  14. Shigetomi, E., Patel, S. & Khakh, B. S. Trends Cell Biol. 26, 300–312 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Robert H. Miller.

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Miller, R.H. Calcium control of myelin sheath growth. Nat Neurosci 21, 2–3 (2018). https://doi.org/10.1038/s41593-017-0043-7

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