A leaky blood–brain barrier may contribute to neuropsychiatric disease. Chronic stress is shown to alter blood–brain barrier permeability, allowing an inflammatory response to penetrate the brain. The deficit is mostly around the nucleus accumbens, an area central to motivation. The affected animals exhibit features of depression.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Debbie Maizels/Springer Nature.
References
Menard, C. et al. Nature Neuroscience https://doi.org/10.1038/s41593-017-0010-3 (2017).
Miller, A. H. & Raison, C. L. Nat. Rev. Immunol. 16, 22–34 (2016).
Hendriksen, E., van Bergeijk, D., Oosting, R. S. & Redegeld, F. A. Neurosci. Biobehav. Rev. 79, 119–133 (2017).
Miller, A. H., Maletic, V. & Raison, C. L. Biol. Psychiatry 65, 732–741 (2009).
Hiles, S. A., Baker, A. L., de Malmanche, T. & Attia, J. Brain Behav. Immun. 26, 1180–1188 (2012).
Hodes, G. E. et al. Proc. Natl. Acad. Sci. USA 111, 16136–16141 (2014).
Wohleb, E. S., Powell, N. D., Godbout, J. P. & Sheridan, J. F. J. Neurosci. 33, 13820–13833 (2013).
Weber, M. D., Godbout, J. P. & Sheridan, J. F. Neuropsychopharmacology 42, 46–61 (2017).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Leonardo, E.D., Dranovsky, A. An opening for humor in melancholy. Nat Neurosci 20, 1657–1658 (2017). https://doi.org/10.1038/s41593-017-0015-y
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41593-017-0015-y
