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An opening for humor in melancholy

A leaky blood–brain barrier may contribute to neuropsychiatric disease. Chronic stress is shown to alter blood–brain barrier permeability, allowing an inflammatory response to penetrate the brain. The deficit is mostly around the nucleus accumbens, an area central to motivation. The affected animals exhibit features of depression.

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Fig. 1: Stress acts on Cldn5 to increase blood–brain barrier permeability and depression-related behaviors.

Debbie Maizels/Springer Nature.


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Correspondence to E. David Leonardo or Alex Dranovsky.

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Leonardo, E.D., Dranovsky, A. An opening for humor in melancholy. Nat Neurosci 20, 1657–1658 (2017).

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