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Unleashing the power of biomaterials to enhance organoid differentiation and function

Nature Methods volume 21, pages 1575–1577 (2024)Cite this article

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Biomaterials are revolutionizing organoid development by offering tunable platforms that provide instructive cues, which enhance cell fate transitions, tissue-level functions and reproducibility. These advances are crucial for harnessing the translational potential of organoids.

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Fig. 1: Biomaterials influencing organoid development and tissue structure.

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Acknowledgements

The authors thank Samane Mahdavian for transforming their original sketch into a graphical illustration and Loren Baugh for comments on the manuscript. This work was supported by an NIH Director’s New Innovator Award (award number DP2DK139544) awarded to S.M.

Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, USA

    Samira Musah & Hamidreza Arzaghi

  2. Center for Biomolecular and Tissue Engineering, Duke University, Durham, NC, USA

    Samira Musah

  3. Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA

    Samira Musah

  4. Developmental and Stem Cell Biology Program, Duke University, Durham, NC, USA

    Samira Musah

  5. Department of Cell Biology, Duke University, Durham, NC, USA

    Samira Musah

Authors
  1. Samira Musah
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  2. Hamidreza Arzaghi
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Contributions

S.M. conceived the idea and strategy for this work. S.M and H.A. wrote the manuscript. H.A. developed the original sketch for the illustration in Fig. 1. S.M. supervised H.A.

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Correspondence to Samira Musah.

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The authors declare no competing interests.

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Nature Methods thanks Shelly Peyton for their contribution to the peer review of this work.

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Musah, S., Arzaghi, H. Unleashing the power of biomaterials to enhance organoid differentiation and function. Nat Methods 21, 1575–1577 (2024). https://doi.org/10.1038/s41592-024-02393-5

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