A class of protein-based molecular shape probes move us closer toward the goal of a general, genetically encoded tagging system for cryogenic electron tomography.
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J.W.T. thanks K. Sochacki for helpful comments and discussions and W. Sun for collecting the cryogenic electron tomogram image. J.W.T. is supported by the Intramural Research Program of the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD and the Chan Zuckerberg Initiative (Visual Proteomics Imaging grant no. 2021-234544).
The author declares no competing interests.
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Taraska, J.W. Genetically encoded shape probes for cryogenic electron tomography. Nat Methods 20, 1874–1876 (2023). https://doi.org/10.1038/s41592-023-02044-1