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Extending support for mouse data in the Molecular Signatures Database (MSigDB)

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Fig. 1: Home page of the MSigDB resource.

Data availability

The MSigDB resource, including both mouse and human gene sets, is freely available at The full GSEA/MSigDB resource is available at

Code availability

The GSEA software is open source under a BSD-style license; the source code is available at MSigDB is available under a Creative Commons license. The full license terms can be found at


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This work was supported by US National Institutes of Health grant U24CA220341 to J.P.M.

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Authors and Affiliations



A.S.C. and J.M.R. developed the ortholog mapping procedure. C.J.B. and J.M.R. identified and curated the gene sets in the MP:Tumor collection; J.M.R. wrote the code to generate the gene sets. J.M.R. and C.J.B. produced the ortholog translated hallmarks collection. D.E. collected existing mouse gene sets from MSigDB. A.S.C. curated all other sets and collections and produced the underlying gene mapping data. A.S.C. and D.E. produced the complete MSigDB build. A.S.C., D.E. and H.T. designed the updates to the MSigDB website; D.E. implemented the updates. A.S.C., H.T. and J.P.M. wrote the manuscript with input and feedback from all authors. C.J.B. and J.P.M. provided oversight and guidance.

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Correspondence to Jill P. Mesirov.

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The authors declare no competing interests.

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Nature Methods thanks Jüri Reimand and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Supplementary Notes 1–5, References and Figs. 1–2

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Supplementary Table 1

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Castanza, A.S., Recla, J.M., Eby, D. et al. Extending support for mouse data in the Molecular Signatures Database (MSigDB). Nat Methods 20, 1619–1620 (2023).

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