We developed CellOT, a tool that integrates optimal transport with input convex neural networks to predict molecular responses of individual cells to various perturbations. By learning a map between the unpaired distributions of unperturbed and perturbed cells, CellOT outperforms current methods and generalizes the inference of treatment outcomes in unobserved cell types and patients.
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This is a summary of: Bunne, C. et al. Learning single-cell perturbation responses using neural optimal transport. Nat. Methods https://doi.org/10.1038/s41592-023-01969-x (2023).
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Neural optimal transport predicts perturbation responses at the single-cell level. Nat Methods 20, 1639–1640 (2023). https://doi.org/10.1038/s41592-023-01968-y