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Circular RNA detection pipelines yield divergent sets of circular RNAs

A decade ago, the first bioinformatics pipelines to detect circular RNA molecules based on short-read sequencing data were published. Here, we show that dozens of such circular RNA detection tools differ vastly in their sensitivity but not in their specificity.

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Fig. 1: CircRNA formation and study design.


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This is a summary of: Vromman, M. et al. Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision. Nat. Methods (2023).

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Circular RNA detection pipelines yield divergent sets of circular RNAs. Nat Methods 20, 1135–1136 (2023).

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