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Photoselective sequencing harnesses microscopy to guide genomic analyses

Photoselective sequencing is a new method for genomic and epigenomic profiling within specific regions of a biological specimen that are chosen using light microscopy. This combination of spatial and sequencing information preserves the connections between genomic and environmental properties and deepens our understanding of structure–function relationships in cells and tissues.

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Fig. 1: Unblocking libraries in cell nuclei.


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This is a summary of: Mangiameli, S. M. et al. Photoselective sequencing: microscopically guided genomic measurements with subcellular resolution. Nat. Methods (2023).

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Photoselective sequencing harnesses microscopy to guide genomic analyses. Nat Methods 20, 647–648 (2023).

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