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Photon-based communication between two neurons in Caenorhabditis elegans

Nature Methods volume 20, pages 653–654 (2023)Cite this article

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Cells exchange information with one another using secreted chemicals as data carriers. We developed an all-optogenetic synaptic transmission system that replaced a chemical neurotransmitter with emitted photons. This system enabled synthetic signaling between unconnected neurons and the generation of prosthetic synaptic circuits.

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Fig. 1: Rewiring a neuronal circuit using PhAST.

References

  1. Emiliani, V. et al. Optogenetics for light control of biological systems. Nat. Rev. Methods Prim. 2, 55 (2022). A review about optogenetics.

    Article  CAS  Google Scholar 

  2. Corsi, A. K., Wightman, B. & Chalfie, M. A transparent window into biology: a primer on Caenorhabditis elegans. Genetics 200, 387–407 (2015). A review concerning C. elegans as a model organism for neuroscience.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Morales-Curiel, L. F. et al. Volumetric imaging of fast cellular dynamics with deep learning enhanced bioluminescence microscopy. Commun. Biol. 5, 1330 (2022). A research paper about bioluminescence microscopy.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Prakash, M. et al. Selective control of synaptically-connected circuit elements by all-optical synapses. Commun. Biol. 5, 33 (2022). A research paper about optical synapses in mice.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Mitiouchkina, T. et al. Plants with genetically encoded autoluminescence. Nat. Biotechnol. 38, 944–946 (2020). A research paper about reconstitution of autoluminescent enzymes.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Nagai, T. & Hattori, M. Tiny but bright. Nat. Chem. Biol. 6, 522–523 (2022). A review about luciferases.

    Google Scholar 

Download references

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This is a summary of: Porta-de-la-Riva, M. et al. Neural engineering with photons as synaptic transmitters. Nat. Methods https://doi.org/10.1038/s41592-023-01836-9 (2023).

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Photon-based communication between two neurons in Caenorhabditis elegans. Nat Methods 20, 653–654 (2023). https://doi.org/10.1038/s41592-023-01837-8

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