Light-activated drugs and signaling molecules have therapeutic potential and are valuable experimental tools. Photoactivation of a mu opioid receptor agonist in the mouse brain rapidly triggered pain relief and locomotion, demonstrating that in vivo photopharmacology can drive dynamic studies into animal behavior.
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References
Paoletti, P., Ellis-Davies, G. C. & Mourot, A. Optical control of neuronal ion channels and receptors. Nat. Rev. Neurosci. 20, 514–532 (2019). This review article presents photopharmacological probes and their biological applications.
Banghart, M. R. & Sabatini, B. L. Photoactivatable neuropeptides for spatiotemporally precise delivery of opioids in neural tissue. Neuron 73, 249–259 (2012). This paper reports the first caged opioid neuropeptides.
Banghart, M. R., He, X. J. & Sabatini, B. L. A caged enkephalin optimized for simultaneously probing mu and delta opioid receptors. ACS Chem. Neurosci. 9, 684–690 (2018). This paper reports second-generation caged opioid neuropeptides.
Banghart, M. R. et al. Light-activated ion channels for remote control of neuronal firing. Nat. Neurosci. 7, 2792–2796 (2004). This paper reports the use of a photoswitchable molecule to control neuronal activity.
Hüll, K., Morstein, J. & Trauner, D. In vivo photopharmacology. Chem. Rev. 118, 10710–10747 (2018). This review article presents photoswitchable ligands that have been examined in vivo.
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This is a summary of: Ma, X. et al. In vivo photopharmacology with a caged mu opioid receptor agonist drives rapid changes in behavior. Nat. Methods https://doi.org/10.1038/s41592-023-01819-w (2023).
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Deep-brain photoactivation of an opioid peptide shapes mouse behavior within seconds. Nat Methods 20, 645–646 (2023). https://doi.org/10.1038/s41592-023-01821-2
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DOI: https://doi.org/10.1038/s41592-023-01821-2
