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Controlling cellular activities with light

New red–green optogenetic dimerizers enable the switching on and off of gene expression with high spatiotemporal precision.

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Fig. 1: BICYCL optogenetic systems for controlling gene expression.


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Y.-W.W. is supported by the European Research Council (ChemBioAP), Vetenskapsrådet (nr 2018-04585), the Knut and Alice Wallenberg Foundation and the Göran Gustafsson Foundation for Research in Natural Sciences and Medicine. The author thanks colleagues at Wu laboratory for discussion, and acknowledges D. Corkery for proofreading of the manuscript.

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Correspondence to Yao-Wen Wu.

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Wu, YW. Controlling cellular activities with light. Nat Methods 20, 357–358 (2023).

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