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SYNTHETIC BIOLOGY

Tracking the order of transcriptional events in living cells

Researchers describe Retro-Cascorder, a tool that employs prokaryotic retrons and CRISPR integrases to write transcriptional events into the genome of Escherichia coli.

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  • Bhattarai-Kline, S. et al. Recording gene expression order in DNA by CRISPR addition of retron barcodes. Nature 608, 217–225 (2022).

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Correspondence to Lei Tang.

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Tang, L. Tracking the order of transcriptional events in living cells. Nat Methods 19, 1031 (2022). https://doi.org/10.1038/s41592-022-01610-3

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  • DOI: https://doi.org/10.1038/s41592-022-01610-3

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