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Sensitive, flexible and modular single-cell multi-omics profiling with ISSAAC-seq

Joint profiling of multiple modalities in the same cell is challenging. We developed a method with a modular design to enable the simultaneous detection of chromatin accessibility and the transcriptome within single cells with flexible throughput.

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Fig. 1: Joint profiling of chromatin accessibility and gene expression using ISSAAC-seq.


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This is a summary of: Xu, W. et al. ISSAAC-seq enables sensitive and flexible multimodal profiling of chromatin accessibility and gene expression in single cells. Nat. Methods (2022).

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Sensitive, flexible and modular single-cell multi-omics profiling with ISSAAC-seq. Nat Methods 19, 1183–1184 (2022).

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