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Why it is important to study human–monkey embryonic chimeras in a dish

The study of human–animal chimeras is fraught with technical and ethical challenges. In this Comment, we discuss the importance and future of human–monkey chimera research within the context of current scientific and regulatory obstacles.

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Fig. 1: Scheme of representative proposed in vitro experiments.


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We thank E. Olson for input and feedback.

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Authors and Affiliations



This work is the product of extensive collaboration and deliberation among all the authors. A.D.L.A. conceived the original idea and wrote the original version of the manuscript. V.M., N.B., G.C., H.D., J.C.I.B., W.J., Y.N., D.P., M.P., N.P., C.P.-A., M.S., J.C.R.S., T.T., A.T., A.R., and E.T.Z. provided conceptual contributions and wrote, edited, and gave final approval to the manuscript. J.K., Y.-H.L., and T.W. helped with editing of the manuscript. A.R. and E.T.Z. provided important conceptual contributions to the final version of the manuscript and, together with A.D.L.A., took the lead in writing, revising, and editing the final versions of the manuscript.

Corresponding author

Correspondence to Alejandro De Los Angeles.

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The authors declare no competing interests.

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Nature Methods thanks Kazuto Kato and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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De Los Angeles, A., Regenberg, A., Mascetti, V. et al. Why it is important to study human–monkey embryonic chimeras in a dish. Nat Methods 19, 914–919 (2022).

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