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Uncovering ubiquitous protein lactylation

A diagnostic fragment ion in tandem mass spectrometry enables confident protein lactylation assignment and the discovery of broad lysine modification beyond histones.

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Fig. 1: Protein lactylation.

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Acknowledgements

This project was funded by NIH grant 1RF1AG064250.

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Correspondence to Xiaofeng Wu or W. Andy Tao.

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Wu, X., Tao, W.A. Uncovering ubiquitous protein lactylation. Nat Methods 19, 793–794 (2022). https://doi.org/10.1038/s41592-022-01536-w

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