TALE-fused deaminases enable C-to-T or A-to-G base editing in human mitochondria.
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Research papers
Cho, S. et al. Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases. Cell 185, 1764–1776.e12 (2022).
Mok, B. Y. et al. CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01256-8 (2022).
Lei, Z. et al. Mitochondrial base editor induces substantial nuclear off-target mutations. Nature https://doi.org/10.1038/s41586-022-04836-5 (2022).
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Tang, L. Base editing in mitochondrial DNA. Nat Methods 19, 640 (2022). https://doi.org/10.1038/s41592-022-01532-0
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DOI: https://doi.org/10.1038/s41592-022-01532-0
