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DEVELOPMENTAL BIOLOGY

Reversing the clock on human somatic cells

Nature Methods volume 19, page 639 (2022)Cite this article

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A chemical cocktail reprograms human somatic cells into pluripotent stem cells.

Researchers at the Peking University in Beijing have now developed a chemical cocktail to reprogram human somatic cells. Inspired by the open chromatin landscape observed in animals like the axolotl that have regenerative abilities, the team decided to screen small molecule regulators to change the epigenetic landscape of human cells.

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Research paper

  • Guan, J. et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 605, 325–331 (2022).

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  1. Nature Methods http://www.nature.com/nmeth

    Madhura Mukhopadhyay

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  1. Madhura Mukhopadhyay
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Correspondence to Madhura Mukhopadhyay.

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Mukhopadhyay, M. Reversing the clock on human somatic cells. Nat Methods 19, 639 (2022). https://doi.org/10.1038/s41592-022-01531-1

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  • DOI: https://doi.org/10.1038/s41592-022-01531-1

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