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Reconstructing whole genome structures using a multi-modal data integration approach

The Integrative Genome Modeling (IGM) platform incorporates information from multiple, complementary experimental data sources to accurately simulate whole diploid genome structures. We show that such structures have high predictive power and give access to a large variety of structural observables for the characterization of the gene microenvironment.

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Fig. 1: Multi-modal data integration to reveal whole genome structure.


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This is a summary of: Boninsegna, L. et al. Integrative genome modeling platform reveals essentiality of rare contact events in 3D genome organizations. Nat. Methods (2022).

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Reconstructing whole genome structures using a multi-modal data integration approach. Nat Methods 19, 934–935 (2022).

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