Global profiling of changes in the reactivity of cysteine residues in response to phosphorylation during mitosis identifies cysteine residues as potential regulatory and drug binding sites on proteins.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Vinogradova, E. V. et al. Cell 182, 1009–1026.e29 (2020).
Backus, K. M. et al. Nature 534, 570–574 (2016).
Maurais, A. J. & Weerapana, E. Curr. Opin. Chem. Biol. 50, 29–36 (2019).
Kemper, E. K. et al. Nat. Methods https://doi.org/10.1038/s41592-022-01398-2 (2022).
Zanon, P. R. A., Lewald, L. & Hacker, S. M. Angew. Chem. Int. Edn Engl. 59, 2829–2836 (2020).
Sharma, K. et al. Cell Rep. 8, 1583–1594 (2014).
This work was supported by the National Institutes of Health grants R01 EB-028628, R01 EB026332, R01 EB026285 and R01 DK130293 to M.B. and a postdoctoral research fellowship by the German Research Foundation (DFG) to M.L.
The authors declare no competing interests.
About this article
Cite this article
Lakemeyer, M., Bogyo, M. Uncovering an overlooked consequence of phosphorylation: change in cysteine reactivity. Nat Methods 19, 281–283 (2022). https://doi.org/10.1038/s41592-022-01414-5