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Deep learning and protein structure modeling

Deep learning has transformed protein structure modeling. Here we relate AlphaFold and RoseTTAFold to classical physically based approaches to protein structure prediction, and discuss the many areas of structural biology that are likely to be affected by further advances in deep learning.

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Fig. 1: RoseTTAFold accurately predicts structures of de-novo-designed proteins from their amino acid sequences.


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This work was supported by Microsoft (M.B., D.B.), Open Philanthropy and HHMI (D.B.) and the Washington Research Foundation (M.B.).

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Correspondence to David Baker.

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Baek, M., Baker, D. Deep learning and protein structure modeling. Nat Methods 19, 13–14 (2022).

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