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Editing naive CD4+ T cells

As last we can edit the immune system’s sleeping giants, as CRISPR tools advance into the world of naive CD4+ T cells.

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Fig. 1: Evolution of CRISPR–Cas9 technology toward gene editing in resting lymphocytes.


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Z.M.N. is supported by an HHMI International Research Scholar award (grant 55008743 to Z.M.N.) and the US National Institutes of Health (NIAID) (R01AI145305 to Z.M.N., R37 AI67073 to BDW). A.O.P is supported by a Bill and Melinda Gates Foundation Grand Challenges grant (INV-016491 to Z.M.N. and grant 55008743 to Z.M.N.). This work used computational facilities at the Africa Health Research Institute (AHRI).

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Correspondence to Zaza Mtine Ndhlovu.

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Papadopoulos, A.O., Ndhlovu, Z.M. Editing naive CD4+ T cells. Nat Methods 19, 36–37 (2022).

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