Researchers identified a single-effector Cas, Cas7-11, that architecturally diverges from previous CRISPR single- or multi-component systems and can possess RNA knockdown activity without detectable collateral activity in mammalian cells.
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Research paper
Özcan, A. et al. Programmable RNA targeting with the single-protein CRISPR effector Cas7-11. Nature 597, 720–725 (2021).
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Tang, L. Expanding RNA target effectors. Nat Methods 18, 1276 (2021). https://doi.org/10.1038/s41592-021-01323-z
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DOI: https://doi.org/10.1038/s41592-021-01323-z