Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

STRUCTURAL BIOLOGY

Neural networks learn the motions of molecular machines

New computational approaches capture molecular motion from cryo-EM images and provide a more complete understanding of protein dynamics.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Two possible motions of the yeast spliceosome, a highly dynamic complex.

References

  1. Zhong, E. D., Bepler, T., Berger, B. & Davis, J. H. Nat. Methods 18, 176–185 (2021).

    Article  CAS  Google Scholar 

  2. Chen, M. & Ludtke, S. Nat. Methods https://doi.org/10.1038/s41592-021-01220-5 (2021).

  3. Yip, K. M., Fischer, N., Paknia, E., Chari, A. & Stark, H. Nature 587, 157–161 (2020).

    Article  CAS  Google Scholar 

  4. Nakane, T. et al. Nature 587, 152–156 (2020).

    Article  CAS  Google Scholar 

  5. Cheng, Y., Grigorieff, N., Penczek, P. A. & Walz, T. Cell 161, 438–449 (2015).

    Article  CAS  Google Scholar 

  6. Punjani, A. & Fleet, D. J. Preprint at bioRxiv https://doi.org/10.1101/2021.04.22.440893 (2021).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Timothy Grant.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Grant, T. Neural networks learn the motions of molecular machines. Nat Methods 18, 869–871 (2021). https://doi.org/10.1038/s41592-021-01235-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41592-021-01235-y

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing