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SEQUENCING

Triangulating spatial relationships from single-cell interaction maps

A combined experimental and computational approach to transcriptomic profiling of cell ‘multiplets’ enables the reconstruction of cell–cell interactions and higher-order structural features of biological tissues.

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Fig. 1: Reconstruction of tissue architectures using CIM-seq.

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Correspondence to Daniel E. Wagner.

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Wagner, D.E. Triangulating spatial relationships from single-cell interaction maps. Nat Methods 18, 867–869 (2021). https://doi.org/10.1038/s41592-021-01221-4

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