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gEAR: Gene Expression Analysis Resource portal for community-driven, multi-omic data exploration

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Fig. 1: gEAR overview.

Code availability

The gEAR code is available on GitHub ( or Zenodo ( and released under the GNU Affero General Public License v3.0.


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We are grateful to the members of the Hearing Restoration Project for serving as the focus group in developing this tool and their continuous feedback. We thank R. Marini for technical assistance. This work was funded by the Hearing Restoration Project (R.H.); R01-DC013817 and R01-DC019370 (R.H.); R24- 96MH114815 (R.H. and O.W.); and R01-GM114267 (H.C.B).

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Authors and Affiliations



Portal design: J.O., B.G., R.S.A., A.M. and R.H. Data archive and infrastructure: J.O., B.G., R.S.A., J.K., M.C.K., H.C.B., S.A.A., C.C., B.H., O.W. and A.M. Graphic design: A.A.D. User interface: J.O., B.G., R.S.A., D.O. and A.M. User manual: J.O., Y.S., K.R., E.C. and R.H. DVD and deafness gene/locus integration: H.A., J.O, and R.H. Providing unpublished data: K.R., M.C.K, M.W.K. and R.H. Project management: R.L.C., A.M. and R.H. Data upload and analysis: J.O., D.O., Y.S., E.C., B.M., M.S.M. and R.H. Writing the manuscript: J.O., B.M., A.M. and R.H.

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Correspondence to Ronna Hertzano.

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The authors declare no competing interests.

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Peer review information Nature Methods thanks Eran Mukamel and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Orvis, J., Gottfried, B., Kancherla, J. et al. gEAR: Gene Expression Analysis Resource portal for community-driven, multi-omic data exploration. Nat Methods 18, 843–844 (2021).

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