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SEQUENCING

Single-cell multiomics to probe relationships between histone modifications and transcription

Two new technologies enable the profiling of single cells for RNA transcription as well as modifications to histone proteins. Each takes a similar strategy to capture both properties, but with different methods for cell indexing, and they are applied to two different areas: neuroscience and developmental biology, respectively.

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Fig. 1: Paired-Tag and CoTECH to simultaneously profile histone modifications and transcription in single cells.

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Correspondence to Andrew C. Adey.

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Adey, A.C. Single-cell multiomics to probe relationships between histone modifications and transcription. Nat Methods 18, 602–603 (2021). https://doi.org/10.1038/s41592-021-01147-x

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