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Single-cell multiomics to probe relationships between histone modifications and transcription

Two new technologies enable the profiling of single cells for RNA transcription as well as modifications to histone proteins. Each takes a similar strategy to capture both properties, but with different methods for cell indexing, and they are applied to two different areas: neuroscience and developmental biology, respectively.

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Fig. 1: Paired-Tag and CoTECH to simultaneously profile histone modifications and transcription in single cells.


  1. 1.

    Zhu, C. et al. Nat. Struct. Mol. Biol. (2019).

  2. 2.

    Cao, J. et al. Science 361, 1380–1385 (2018).

    CAS  Article  Google Scholar 

  3. 3.

    Ma, S. et al. Cell 183, 1103–1116.e20 (2020).

    CAS  Article  Google Scholar 

  4. 4.

    Zhu, C. et al. Nat. Methods 18, 283–292 (2021).

    CAS  Article  Google Scholar 

  5. 5.

    Xiong, H., Luo, Y., Wang, Q., Yu, X. & He, A. Nat. Methods (2021).

  6. 6.

    Kaya-Okur, H. S. et al. Nat. Commun. 10, 1930 (2019).

    Article  Google Scholar 

  7. 7.

    Carter, B., Ku, W. L., Tang, Q. & Zhao, K. Nat. Commun. 10, 571208 (2019).

    Article  Google Scholar 

  8. 8.

    Wang, Q. et al. Mol. Cell 76, 206–216.e7 (2019).

    CAS  Article  Google Scholar 

  9. 9.

    Domcke, S. et al. Science 370, eaba7612 (2020).

    CAS  Article  Google Scholar 

  10. 10.

    Stergachis, A. B. et al. Cell 154, 888–903 (2013).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Andrew C. Adey.

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Adey, A.C. Single-cell multiomics to probe relationships between histone modifications and transcription. Nat Methods 18, 602–603 (2021).

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