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STEM CELLS

A small-molecule cocktail that beats cellular stress

CEPT, a small-molecule cocktail, improves the viability of human pluripotent stem cells, protects cells during culture and cryopreservation, and promotes in vitro differentiation and organoid formation.

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Fig. 1: Applications of CEPT in basic and translational research using hiPSCs.

References

  1. 1.

    Deinsberger, J., Reisinger, D. & Weber, B. NPJ Regen. Med. 5, 15 (2020).

    Article  Google Scholar 

  2. 2.

    Chen, Y. et al. Nat. Meth. https://doi.org/10.1038/s41592-021-01126-2 (2021).

    Article  Google Scholar 

  3. 3.

    Thomson, J. A. et al. Science 282, 1145–1147 (1998).

    CAS  Article  Google Scholar 

  4. 4.

    Watanabe, K. et al. Nat. Biotechnol. 25, 681–686 (2007).

    CAS  Article  Google Scholar 

  5. 5.

    Ohgushi, M. et al. Cell Stem Cell 7, 225–239 (2010).

    CAS  Article  Google Scholar 

  6. 6.

    Takahashi, K. et al. Cell 131, 861–872 (2007).

    CAS  Article  Google Scholar 

  7. 7.

    Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    CAS  Article  Google Scholar 

  8. 8.

    Kitahata, S. et al. Sci. Rep. 9, 2891 (2019).

    Article  Google Scholar 

Download references

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Correspondence to Rajarshi Pal.

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Pal, R. A small-molecule cocktail that beats cellular stress. Nat Methods 18, 457–458 (2021). https://doi.org/10.1038/s41592-021-01127-1

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