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STRUCTURAL BIOLOGY

A community effort to bring structure to disorder

With protein structure prediction recently getting a seismic boost in accuracy, hopes are also up to better predict unstructured protein regions that can adopt diverse conformations. CAID, a community effort to revive systematic benchmarking, should help.

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Fig. 1: The Critical Assessment of Protein Intrinsic Disorder prediction (CAID) is a new biennial challenge for predicting unstructured protein regions and binding regions within them.

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Acknowledgements

We thank B. J. Leslie and X. Li for comments on the manuscript. This work is supported by funding from ALSAC.

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Correspondence to Benjamin Lang or M. Madan Babu.

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Lang, B., Babu, M.M. A community effort to bring structure to disorder. Nat Methods 18, 454–455 (2021). https://doi.org/10.1038/s41592-021-01123-5

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