Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


A community effort to bring structure to disorder

With protein structure prediction recently getting a seismic boost in accuracy, hopes are also up to better predict unstructured protein regions that can adopt diverse conformations. CAID, a community effort to revive systematic benchmarking, should help.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: The Critical Assessment of Protein Intrinsic Disorder prediction (CAID) is a new biennial challenge for predicting unstructured protein regions and binding regions within them.


  1. 1.

    van der Lee, R. et al. Chem. Rev. 114, 6589–6631 (2014).

    Article  Google Scholar 

  2. 2.

    Tompa, P., Davey, N. E., Gibson, T. J. & Babu, M. M. Mol. Cell 55, 161–169 (2014).

    CAS  Article  Google Scholar 

  3. 3.

    Phillips, A. H. & Kriwacki, R. W. Curr. Opin. Struct. Biol. 60, 1–6 (2020).

    CAS  Article  Google Scholar 

  4. 4.

    Perdigao, N. et al. Proc. Natl Acad. Sci. USA 112, 15898–15903 (2015).

    CAS  Article  Google Scholar 

  5. 5.

    Callaway, E. Nature 588, 203–204 (2020).

    CAS  Article  Google Scholar 

  6. 6.

    Nielsen, J. T. & Mulder, F. A. A. Sci. Rep. 9, 5137 (2019).

    Article  Google Scholar 

  7. 7.

    Necci, M., Piovesan, D., CAID Predictors, DisProt Curators & Tosatto, S. C. E. Nat. Methods (2021).

  8. 8.

    Hatos, A. et al. Nucleic Acids Res. 48, D269–D276 (2020).

    CAS  PubMed  Google Scholar 

  9. 9.

    Hanson, J., Paliwal, K. K., Litfin, T. & Zhou, Y. Genomics Proteomics Bioinformatics 17, 645–656 (2019).

    Article  Google Scholar 

  10. 10.

    Rowell, J. P., Simpson, K. L., Stott, K., Watson, M. & Thomas, J. O. Structure 20, 2014–2024 (2012).

    CAS  Article  Google Scholar 

Download references


We thank B. J. Leslie and X. Li for comments on the manuscript. This work is supported by funding from ALSAC.

Author information



Corresponding authors

Correspondence to Benjamin Lang or M. Madan Babu.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Lang, B., Babu, M.M. A community effort to bring structure to disorder. Nat Methods 18, 454–455 (2021).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing