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STRUCTURAL BIOLOGY

A community effort to bring structure to disorder

With protein structure prediction recently getting a seismic boost in accuracy, hopes are also up to better predict unstructured protein regions that can adopt diverse conformations. CAID, a community effort to revive systematic benchmarking, should help.

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Fig. 1: The Critical Assessment of Protein Intrinsic Disorder prediction (CAID) is a new biennial challenge for predicting unstructured protein regions and binding regions within them.

References

  1. van der Lee, R. et al. Chem. Rev. 114, 6589–6631 (2014).

    Article  Google Scholar 

  2. Tompa, P., Davey, N. E., Gibson, T. J. & Babu, M. M. Mol. Cell 55, 161–169 (2014).

    Article  CAS  Google Scholar 

  3. Phillips, A. H. & Kriwacki, R. W. Curr. Opin. Struct. Biol. 60, 1–6 (2020).

    Article  CAS  Google Scholar 

  4. Perdigao, N. et al. Proc. Natl Acad. Sci. USA 112, 15898–15903 (2015).

    Article  CAS  Google Scholar 

  5. Callaway, E. Nature 588, 203–204 (2020).

    Article  CAS  Google Scholar 

  6. Nielsen, J. T. & Mulder, F. A. A. Sci. Rep. 9, 5137 (2019).

    Article  Google Scholar 

  7. Necci, M., Piovesan, D., CAID Predictors, DisProt Curators & Tosatto, S. C. E. Nat. Methods https://doi.org/10.1038/s41592-021-01117-3 (2021).

  8. Hatos, A. et al. Nucleic Acids Res. 48, D269–D276 (2020).

    CAS  PubMed  Google Scholar 

  9. Hanson, J., Paliwal, K. K., Litfin, T. & Zhou, Y. Genomics Proteomics Bioinformatics 17, 645–656 (2019).

    Article  Google Scholar 

  10. Rowell, J. P., Simpson, K. L., Stott, K., Watson, M. & Thomas, J. O. Structure 20, 2014–2024 (2012).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank B. J. Leslie and X. Li for comments on the manuscript. This work is supported by funding from ALSAC.

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Correspondence to Benjamin Lang or M. Madan Babu.

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Lang, B., Babu, M.M. A community effort to bring structure to disorder. Nat Methods 18, 454–455 (2021). https://doi.org/10.1038/s41592-021-01123-5

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