Fig. 1: Methods workflow. | Nature Methods

Fig. 1: Methods workflow.

From: Investigating higher-order interactions in single-cell data with scHOT

Fig. 1

a, Example showing a differentiation trajectory where genes are tested for changes in higher-order interactions such as variability and correlation along the trajectory. A set of local higher-order statistics are calculated, and significance is compared by repeatedly permuting samples (gray curves). The local estimates of higher-order statistics are combined using the sample standard deviation to assess variability across time. b, Example showing that in a spatial context, scHOT calculates a field of local estimates of correlation across space and compares the variability associated with these with permuted sample points across space.

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