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Molecular biology

Mapping m6A and m1A with mutation signatures

In two novel RNA modification mapping methods, the authors have engineered RNA enzymes and used the enzyme-mediated mutational signatures to map m6A and m1A at single-nucleotide resolution in mammalian RNA.

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Fig. 1: Technical advances to detect m6A and m1A between 1974 and 2019.

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Correspondence to Dan Ohtan Wang.

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Wang, D.O. Mapping m6A and m1A with mutation signatures. Nat Methods 16, 1213–1214 (2019). https://doi.org/10.1038/s41592-019-0636-z

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