In two novel RNA modification mapping methods, the authors have engineered RNA enzymes and used the enzyme-mediated mutational signatures to map m6A and m1A at single-nucleotide resolution in mammalian RNA.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Meyer, K. D. Nat. Methods https://doi.org/10.1038/s41592-019-0570-0 (2019).
Zhou, H. et al. Nat. Methods https://doi.org/10.1038/s41592-019-0550-4 (2019).
Linder, B. et al. Nat. Methods 12, 767–772 (2015).
Garcia-Campos, M. A. et al. Cell 178, 731–747 (2019).
Zhang, Z. et al. Sci. Adv. 5, eaax0250 (2019).
Safra, M. et al. Nature 551, 251–255 (2017).
Dominissini, D. et al. Nature 530, 441–446 (2016).
Li, X. et al. Mol. Cell 68, 993–1005 (2017).
Vilfan, I. D. et al. J. Nanobiotechnol. 11, 8 (2013).
Desrosiers, R., Friderici, K. & Rottman, F. Proc. Natl Acad. Sci. USA 71, 3971–3975 (1974).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wang, D.O. Mapping m6A and m1A with mutation signatures. Nat Methods 16, 1213–1214 (2019). https://doi.org/10.1038/s41592-019-0636-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41592-019-0636-z