Koho, S. et al. Nat. Commun. 10, 3103 (2019).

Descloux, A. et al. Nat. Methods https://doi.org/10.1038/s41592-019-0515-7 (2019).

The Fourier ring correlation (FRC) and related Fourier shell correlation methods have widely been used for analyzing resolution in cryoelectron microscopy. More recently, the FRC has been used as a metric to assess image resolution in fluorescence microscopy, especially localization microscopy. Koho et al. now extend the FRC beyond an estimate of image resolution, for image restoration. The researchers show how the FRC can aid image de-noising and can be used to estimate the point-spread-function of a microscope to enable blind linear and non-linear image deconvolution. The authors also show how the FRC can be used to estimate image resolution from a single image, rather than two images that are conventionally required. Estimating image resolution from a single image is also achieved by Descloux et al. in this issue.