The interpretation of fragmentation patterns in tandem mass spectrometry is crucial for peptide sequencing, but the relative intensities of these patterns are difficult to predict computationally. Two groups have applied deep neural networks to address this long-standing problem in the proteomics field, extending theoretical spectra with an additional dimension of high-accuracy fragment ion intensities.
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Generating high quality libraries for DIA MS with empirically corrected peptide predictions
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Röst, H.L. Deep learning adds an extra dimension to peptide fragmentation. Nat Methods 16, 469–470 (2019). https://doi.org/10.1038/s41592-019-0428-5
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DOI: https://doi.org/10.1038/s41592-019-0428-5
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Generating high quality libraries for DIA MS with empirically corrected peptide predictions
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