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Peering into cells at high resolution just got easier

Light-sheet fluorescence microscopes are making it possible to follow subcellular dynamics with unprecedented detail, but they are complex to build and maintain. A new method that can generate arbitrary light sheets provides much-needed simplicity and additional versatility.

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Fig. 1: Field synthesis can generate arbitrary light sheets, including dithered lattice light sheets.

Katie Vicari and Kim Caesar/Springer Nature


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The author acknowledges J. Madrid-Wolff for comments.

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Correspondence to Manu Forero-Shelton.

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The author declares no competing interests.

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Forero-Shelton, M. Peering into cells at high resolution just got easier. Nat Methods 16, 293–294 (2019).

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